AOR Ortho-Core. Ortho-Core is the most advanced, balanced, and comprehensive core nutritional supplement available. Ortho-Core is formulated with a broad spectrum of vitamins, minerals, and phytonutrients whose role in supporting optimal health is backed by scientific research. Unique features of Ortho-Core include the presence of the complete E-complex, the newly discovered classic B (redox-cofactor) nutrient pyrroloquinoline quinone, a broad spectrum of key phytonutrients and substrates for detoxification reactions, the formulation of dosages based on published human epidemiology, and the use of superior forms of nutrients, such as Se-methylselenocysteine and Menatetrenone

Ingredients
Size: 180 Vegi-Caps
Serving Size: 6 Capsules

Vitamins

Vitamin A Complex
-Retinol (Palmitate) 200mcg/110 mcg RAE
Natural-Source Mixed Carotenoids:
Beta-carotene 1.8 mg
Cryptoxanthin 250mcg 208 IU
Lutein 6.8mg
Astaxanthin 2mg
Lycopene 5mg
Vitamin B Complex
B1 (Thiamine) 9mg
B2 (Riboflavin) 2.5mg
B3 (Niacin)(as 126 mg Inositol Hexanicotinate) 115mg
B5 (d-Ca Pantothenate) 100mg
B6 (Pyridoxal 5 Phosphate) 100mg
B12 (Methylcobalamin) 647mcg
Folic Acid (5-methyltetrahydrofolate) 800mcg
Biotin 300mcg
Choline (from Bitartrate) 100mg
Inositol 100mg
Vitamin C Complex
-Vitamin C (as Magnesium Ascorbate) 120mg
-Mixed Citrus Bioflavonoids 25mg
Vitamin D3 (Cholecalciferol) 25mcg 1000 IU
Vitamin E Complex
Mixed Tocopherols:
RRR-Alpha-Tocopherol 99.6mg
Gamma-Tocopherol 13.8mg
Delta-Tocopherol 58.2mg
Mixed Tocotrienols: 27.6mg
alpha-tocotrienol 10mg
gamma-tocotrienol 3mg
delta-tocotrienol 5.5mg
Vitamin K2 Menatetrenone 120mcg

Minerals

Boron (Citrate) 700mcg
Calcium (Calcium carbonate, Citrate-Malate, d-Ca Pantothenate) 300mg
Chromium (Picolinate) 100mcg
Copper (Citrate) 1.5mg
Iodine (Potassium Iodide) 150mcg
Magnesium (Aspartate, Oxide, Ascorbate, Chlorophyllin) 210mg
Potassium (Chloride) 50mg
Manganese (Glycinate) 2.3mg
Molybdenum (Na Molybdate) 45mcg
Selenium (Selenomethionine) 55mcg
Silicon (Na Metasilicate) 25mg
Vanadium (Picolinate) 18mcg
Zinc (Citrate) 11mg
Phytonutrients & Antioxidants
Trans-Resveratrol 1.8mg
Grape Seed Extract (85% Oligomeric proanthocyanidins) 100mg
Alpha-Lipoic Acid 150mg
Co-Enzyme Q10 (ubidecarenone) 30mg
Green Tea Extract (45% EgCG) 140mg
N-Acetylcysteine (NAC) 200mg
Quercetin (dihydrate) 65mg

Sources: Tocopherols: soy. Tocotrienols: palm.

Other ingredients: <3% corn starch, gelatin, ~0.4% soy and vegetable oil, ~0.3% sucrose, silicon dioxide, calcium phosphate, maltodextrin, Acacia gum, ascorbyl palmitate, sorbitan monostearate, gum Arabic, < 0.003% coconut oil, dl-alpha tocopherol.

Capsule: gelatin and water.

AOR guarantees that no ingredients not listed on the label have been added to the product. Contains no wheat, gluten, nuts, dairy, eggs, fish, or shellfish.

Suggested Use
Take up to nine capsules daily with meals, or as directed by a qualified health practitioner.

Main Applications
As reported by literature:

•Vitamin/Mineral Phytonutrient complex.

Source
Multi-Sourced.

Pregnancy / Nursing
No Studies. Best to avoid.

Cautions
Persons taking anticoagulant (“blood thinning”) medications such as warfarin (Coumadin) must not take this supplement. Consult your physician if taking any prescription drugs, as phytonutrients in this supplement may affect their metabolism or bioavailability.

AOR Ortho-Core Multi-Vitamin Research

We have reached a stage where the consumption of a daily multivitamin for optimal health has become all but incontestable. However, those of us who have chosen to take control of our own health must not be content to rest on our laurels with this fact. There is a distinction between deficiencies and imbalances, and this distinction is critical.

Deficiencies vs. Imbalances
It has been well-established that the diet of mainstream society is rampantly deficient in essential nutrients. The need to redress these deficiencies has necessitated the existence of multivitamin formulations, and these formulations react to perceived deficiencies. If a study suggests we are not getting enough vitamin A, supplement manufacturers will often add an arbitrarily large amount of vitamin A to their multivitamin formulations. If another study emphasizes the importance of zinc, large amounts of zinc might be added in similar fashion. While this might make some short-term sense, it does not take into account that all nutrients work together and in synergy. For example, zinc depends on copper for optimum utilization, preferably in a 10 to 1 ratio. Therefore, any supplement manufacturer who adds more zinc to their multivitamin formulation will have to increase copper content proportionately. Failure to do so will result in an imbalance of this important ratio, leading to the suppression of copper-based antioxidant enzymes. Another example of these arbitrarily conceived amounts are the B-complex vitamins. One might be struck by the fact that multivitamins always seem to list their B-complex in precisely the same amounts. It is always the same 50 or 100 milligrams for each and every B vitamin (except for folic acid). What are the chances of the body optimally needing precisely the same amounts of half a dozen different B vitamins, each with its own exclusive biological role to play?

Quality vs. Quantity
The imbalance created by adding disproportionate amounts of certain nutrients is compounded by the fact that the composition of those nutrients is too often not of the optimal source. Therefore, excessive amounts of these synthetic and/or inferior nutrients can be at best wasteful, and at worst toxic or even harmful. Some studies have shown that extreme amounts of synthetic beta-carotene, for example, can lead to the body`s carcinogen-detoxifying network becoming unbalanced, resulting (astonishingly) in the activation of genes related to the cancer process.

So what is the answer to this random, arbitrary, ad-hoc approach to the formulation of daily multivitamins? The short answer is vigilance, especially from consumers, health professionals and supplement manufacturers. Vigilance in this case leads to a product called Ortho-Core.

Enter the Core
It was precisely the imbalances of this "mega-dose and hope for the best" archetype that led scientists at Advanced Orthomolecular Research (AOR) to develop Ortho-Core. Ortho-Core sets itself apart from other multivitamins in two ways: the first is that it does not concern itself with mega-doses. Instead, it pays extraordinary attention to balancing ratios of essential nutrients to one another in order to achieve a synergistic result. Secondly, it pays meticulous attention to combining diversely superior sources of those essential nutrients and balancing their ratios for optimal synergy as well. Here are some of the essential components of Ortho-Core:

Vitamin A Complex: Ortho-Core`s vitamin A is a far cry from the mega-dose of beta-carotene found in some other "cutting edge" formulations. It contains the optimal dosage combined with an innovative diversity of carotenoids that includes alpha and beta carotene, lutein, zeaxanthin and lycopene. Even these diverse micronutrients are selected for an optimal ratio. Ortho-Core`s full-spectrum vitamin A complex even encompasses an effective dose of astaxanthin, a unique carotenoid that even on its own has demonstrated effectiveness in clinical studies for eye, gastrointestinal and cardiovascular health.

Vitamin B Complex: There is no 50 or 100 milligrams across the board here. The amount for each and every B vitamin is selected for the body`s most efficient utilization. Furthermore, Ortho-Core includes B-vitamins in their effective co-enzyme forms, including methylcobalamin and pyridoxal-5`-phosphate, the active co-enzyme forms of B-12 and B-6 respectively.

Vitamin E Complex: Vitamin E is a complex that consists of eight different molecules. Most supplements contain only one vitamin E molecule: alpha-tocopherol, which actually lowers the levels of the other E molecules. The most common E molecule in food (and in Ortho-Core), is gamma-tocopherol. New evidence suggests that gamma-tocopherol, far more than alpha-tocopherol, could yield remarkable results against cancer, heart disease, and Alzheimer`s disease.

Vitamin C Complex: Ortho-Core`s vitamin C complex begins with a powerful dose of magnesium ascorbate, but it also contains a bioflavonoid mix that includes Quercetin. This ubiquitous micronutrient is known for preserving mitochondrial function in heart cells as well as inhibiting the androgen receptors involved in the development and progression of prostate cancer.

Zinc-Copper Balance: Ortho-Core includes a safe and optimal ratio of these two interdependent essential minerals.

Trace Minerals: Official government nutrition panels only recognize 13 essential vitamins and 15 essential minerals. Recently, chromium was added to the latter, but the evidence is compelling that boron, silicon, and vanadium are just as necessary to maintain health, and Ortho-Core includes them all.

Phytonutrients: These are the thousands of biologically active substances found in plants, and many have been shown to be protective, disease-preventing compounds. Ortho-Core contains the phytonutrients most strongly supported by studies on humans, including pomegranate and sulforaphane.

Biotransformation Conjugates: These are a series of diverse and effective compounds designed to enhance the already-formidable nutrient arsenal of Ortho-Core. These include epigallocatechin gallate, or EgCG, the active ingredient in green tea with anti-carcinogenic properties that are supported by extensive volumes of research. Also included are R(+)- lipoic acid and Co-enzyme Q10. These enhancers of the mitochondria (the ‘powerhouse` of the cell) have long been part of the standard regimens of those truly determined to take charge of their own health. R(+)- lipoic acid and Co-enzyme Q10 also work synergistically with vitamins C and E, as well as n-acetylcysteine, or NAC, all of which are included in Ortho-Core.

Ortho-Core was formulated to lead the pack, not follow it. Nor was it meant to rest on its laurels. This is reflected in the meticulous research involved from its inception to its manufacture - and its continuous improvement. The next time you make a choice in selecting your daily multivitamin, it would help to remember that a monsoon can be just as destructive as a drought, and that the latest forecast is always the most valuable.

References
Rygh O. Reserches sur les oligo elements. "I. Des l`importance du strontium, du baryum, du thallium et du zinc dans les scorbuts." Bull Soc Chim Biol. 1949;31:1052. Cited by (17, 19)

Schroeder HA, Tipton IH, Nason AP. "Trace metals in man: strontium and barium." J Chronic Dis. 1972 Sep; 25(9):491-517

Paolini M, Antelli A, Pozzetti L, Spetlova D, Perocco P, Valgimigli L, Pedulli GF, Cantelli-Forti G. "Induction of cytochrome P450 enzymes and over-generation of oxygen radicals in beta-carotene supplemented rats." Carcinogenesis. 2001 Sep; 22(9); 1483-95

Liu C, Wang XD, Bronson RT, Smith DE, Krinsky NI, Russell RM. "Effects of physiological versus pharmacological beta-carotene supplementation on cell proliferation and histopathological changes in the lungs of cigarette smoke-exposed ferrets. Carcinogenesis. 2000 Dec;21(12): 2245-53

Stites TE, Rucker RB. "Physiological importance of quinoenzymes and the O-quinone family of cofactors.` J Nutr. 2000 Apr;130(4):719-27

Kasahara T, Kato T. Nutritional biochemistry: A new redox-cofactor vitamin for mammals. Nature. 2003. April 24;422(6934):832.

Yuan H, Gong A, Young CY. "Involvement of transcription factor Sp1 in quercetin-mediated inhibitory effect on the androgen receptor in human prostate cancer cells." Carcinogenesis. 2005 Apr;26(4):793-801. Epub 2005 Jan 20.

Sawaki K, et al. (2002) Sports performance benefits from taking natural astaxanthin characterized by visual activity and muscle improvements in humans. Journal of Clinical Therapeutics & Medicine 18(9): 73-88.

Mukhtar H, Ahmad N. Tea polyphenols: prevention of cancer and optimizing health. Am J Clin Nutr. 2000 Jun; 71(6 Suppl): 1698S-702S.

Hagen TM, Ingersoll RT, Lykkesfeldt J, Liu J, Wehr CM, Vinarsky V, Bartholomew JC, Ames AB. (R)-alpha-lipoic acid-supplemented old rats have improved mitochondrial function, decreased oxidative damage, and increased metabolic rate. FASEB J. 1999 Feb;13(2):411-8.

Baggio E, Gandini R, Plancher AC, et al. Italian multicenter study on the safety and efficacy of coenzyme Q10 as adjunctive therapy in heart failure. Mol Aspects Med. 1994; 15(Suppl):287-294.

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